A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular types with recombination purpose.
‘It absolutely was only a issue of selecting up a ebook on cell biology and beginning to go through. I had originate from a entire world of ultra-high vacuums, cryostats and quantum phenomena, and now I used to be Functioning at room temperature with molecular biology kits.
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. Within just just a few months, we were being capable to measure transportation through someone single-walled carbon nanotube. Determined by reduced-temperature experiments by an excellent PhD student in my team, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Energetic research lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being genuine quantum wires with incredibly long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
Several relevant developments adopted, the place our team recognized unique transistor variants which include one-electron transistors at home temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled multiple transistors into small proof-of-basic principle Digital circuits.
Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim from the pore is highlighted in pink, as well as a 3D rendering of the motion of your DNA rod is shown.
The rotors harness Vitality from a nanoscale h2o and ion circulation that's created by a static chemical or electrochemical likely gradient inside the nanopore, which are founded by way of a salt gradient or used voltage, respectively. These synthetic nanoengines self-organize and run autonomously in physiological situations, suggesting ways to setting up Power-transducing motors at nanoscale interfaces.
Very great, but that wasn’t definitely exactly where my fascination lay. I needed to pioneer and I had the sensation which was no longer achievable, as the most interesting basic insights experienced now been uncovered. But my field had designed lots of thrilling new equipment to evaluate unique molecules. I decided that I wished to implement this to biology, to have a look at it from the physical perspective.’
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2008, 1st observation of protein-coated DNA translocation by way of nanopores; solved the origin in the electrophoretic power on DNA in nanopores; identified a major velocity cees dekker boost of microtubules in electric fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
2013, controlled shaping of Stay bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations from the handedness of histone tetrasomes